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. 2017 Oct 12;103(1):95–104. doi: 10.1210/jc.2017-01306

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This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).

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Figure 1. — Study protocol schematic. The NK3Ra MLE4901 was administered orally to 13 healthy women for 7 days starting on cycle day 5 to 6. Reproductive hormones were measured and TV USS was performed pretreatment, on days 2, 4, 6, and 8 during the study, and then every 2 to 4 days until ovulation. Urine samples were collected daily until the next menstrual period. LH pulsatility (n = 8) was assessed during 8 hours of blood sampling every 10 minutes on day 6 or 7 of NK3Ra administration or on the equivalent day of the control cycle. Reproductive hormones and ultrasound scan findings were compared with those of the control cycle, the order of which was randomized. BD, twice daily; LMP, last menstrual period; NMP, next menstrual period; TV USS, transvaginal ultrasonography.