Table 4.
HRs and 95% CIs for Prenatal DES Exposure and Self-Reported CVD
| Condition |
DES-Exposed |
DES-Unexposed |
HRa (95% CI) | HRb (95% CI) | ||
|---|---|---|---|---|---|---|
| Participants, n (%) | Person-Years | Participants, n | Person-Years | |||
| Total | 3941 (100) | 1705 (100) | ||||
| CAD | 64 (1.6) | 64,149 | 23 (1.4) | 28,002 | 1.74 (1.03–2.93) | 1.81 (1.07–3.04) |
| MI | 44 (1.1) | 64,264 | 14 (0.8) | 27,992 | 2.20 (1.15–4.21) | 2.21 (1.15–4.25) |
| Stroke | 34 (0.9) | 64,174 | 19 (1.1) | 28,078 | 1.01 (0.54–1.90) | 1.10 (0.58–2.09) |
| Total CVDc | 126 (3.2) | 63,737 | 55 (3.3) | 27,799 | 1.31 (0.93–1.86) | 1.36 (0.96–1.92) |
a
Adjusted for birth year and DES cohort.
b
Adjusted for birth year, cohort, BMI, smoking status, alcohol use, education, number of general physical examinations, age at menarche, menopausal status, and postmenopausal hormone use.
c
Includes women with CAD, MI, and/or stroke; the number of cases for the CVD category does not match the sum of the individual conditions because participants could have multiple conditions.