Table 3.
Baseline Cellular Aging (1 SD Decrease) | 10-y Δ Waist Circumference |
10-y Δ Triglycerides |
10-y Δ HDL Cholesterol |
10-y Δ Systolic BP |
10-y Δ Fasting Glucose |
10-y Δ Number of Dysregulationsa |
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
B | SE | P | B | SE | P | B | SE | P | B | SE | P | B | SE | P | B | SE | P | |
MtDNA (per 141 ↓) | 0.327 | 0.245 | 0.18 | −0.023 | 0.022 | 0.30 | 0.017 | 0.010 | 0.09 | 0.452 | 0.460 | 0.33 | −0.037 | 0.036 | 0.31 | −0.006 | 0.033 | 0.86 |
TL (per 481 ↓) | −0.304 | 0.231 | 0.19 | −0.036 | 0.021 | 0.09 | −0.003 | 0.009 | 0.74 | −0.147 | 0.437 | 0.74 | −0.013 | 0.034 | 0.70 | −0.015 | 0.031 | 0.64 |
Adjusted for age, sex, education, race, smoking, alcohol, and physical activity.
Metabolic dysregulations defined as waist circumference >102 cm (men) or >88 cm (women); triglycerides >1.7 mmol/L; HDL cholesterol <1.03 mmol/L (men) or <1.30 mmol/L (women); systolic BP >130 or diastolic BP >85 mm Hg or antihypertensives; fasting glucose >6.1 mmol/L or antidiabetic medication.