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. 2017 Oct 18;103(1):148–157. doi: 10.1210/jc.2017-01625

Table 3.

Linear Regressions With Baseline mtDNAcn and TL Predicting 10-Year Changes in MetS Components (n = 989)

Baseline Cellular Aging (1 SD Decrease) 10-y Δ Waist Circumference
10-y Δ Triglycerides
10-y Δ HDL Cholesterol
10-y Δ Systolic BP
10-y Δ Fasting Glucose
10-y Δ Number of Dysregulationsa
B SE P B SE P B SE P B SE P B SE P B SE P
MtDNA (per 141 ↓) 0.327 0.245 0.18 −0.023 0.022 0.30 0.017 0.010 0.09 0.452 0.460 0.33 −0.037 0.036 0.31 −0.006 0.033 0.86
TL (per 481 ↓) −0.304 0.231 0.19 −0.036 0.021 0.09 −0.003 0.009 0.74 −0.147 0.437 0.74 −0.013 0.034 0.70 −0.015 0.031 0.64

Adjusted for age, sex, education, race, smoking, alcohol, and physical activity.

a

Metabolic dysregulations defined as waist circumference >102 cm (men) or >88 cm (women); triglycerides >1.7 mmol/L; HDL cholesterol <1.03 mmol/L (men) or <1.30 mmol/L (women); systolic BP >130 or diastolic BP >85 mm Hg or antihypertensives; fasting glucose >6.1 mmol/L or antidiabetic medication.