Table 5.
Linear Regressions With 10-Year Changes in MetS Predicting 10-Year Changes in mtDNAcn and TL (n = 989)
| 10-y Δ Predictors (per SD Change) | 10-y Δ mtDNAcn | 10-y Δ TL | ||||
|---|---|---|---|---|---|---|
| B | SE | P | B | SE | P | |
| Waist circumference (+13.8 cm) | −5.63 | 6.58 | 0.39 | −27.61 | 13.71 | 0.04 |
| Triglycerides (+1.21 mmol/L) | −4.67 | 6.27 | 0.46 | −8.50 | 13.08 | 0.52 |
| HDL cholesterol (+0.36 mmol/L) | −3.74 | 4.24 | 0.38 | 3.38 | 8.82 | 0.70 |
| Systolic BP (+13.7 mm Hg) | −4.64 | 3.48 | 0.18 | −2.48 | 7.26 | 0.73 |
| Fasting glucose (+0.72 mmol/L) | −0.38 | 2.50 | 0.88 | −7.10 | 5.27 | 0.18 |
| Number of metabolic dysregulationsa | −1.27 | 3.53 | 0.72 | −7.15 | 7.37 | 0.33 |
Adjusted for age, sex, education, race, smoking, alcohol, physical activity, baseline predictor, and baseline cellular aging marker.
a
Metabolic dysregulations defined as waist circumference >102 cm (men) or >88 cm (women); triglycerides >1.7 mmol/L; HDL cholesterol <1.03 mmol/L (men) or <1.30 mmol/L (women); systolic BP >130 or diastolic >85 mm Hg or antihypertensives; fasting plasma glucose >6.1 mmol/L or antidiabetic medication.