Fig. 2.

Hazard ratios (HRs) for OS in univariate and adjusted Cox regression models, according to the presence or absence of mutations or CNVs on each LGG subtype. (A, B, C) Hazard ratios and their 95% CIs plotted for mutations, focal and broad CNVs, and signaling pathways in each LGG subtype, from univariate (blue) and age- and WHO grade–adjusted (red) Cox regression models. Results of HRs and 95% CIs are shown on a log₁₀ scale. (D) Among genetic alterations significantly associated with poor prognosis in univariate Cox analysis of IDH-wildtype LGGs, positive (red) and negative (blue) correlations were detected. Size and color gradients of each circle indicate the level of significance as expressed by Q-values and odds ratios of correlations, respectively. TERT promoter mutation, gain of chromosome 7p, and loss of chromosome 10q were strongly correlated and are indicated by yellow bars. RTK-PI3K-mTOR = receptor tyrosine kinase-phosphoinositide 3-kinase-mammalian target of rapamycin; SWI/SNF = SWItch/sucrose non-fermentable; HMT = histone methyltransferase.