Fig. 3.

OS in each LGG subtype, according to prognostic factors. (A, B) OS of patients with Oligodendroglioma IDH-mut/1p19q-codel according to the presence or absence of prognostic factors, including NOTCH1 mutations and extent of resection (partial resection), in the (A) JPN and (B) TCGA cohorts. For comparison, survival curves for patients with Astrocytoma IDH-mut are also presented. (C, D) OS of patients with Astrocytoma IDH-mut according to the presence and absence of prognostic factors, including PIK3R1 mutations and altered RB pathway genes, in the (C) JPN and (D) TCGA cohorts. For comparison, survival curves for patients with GBM, IDH-mutant from the cohort from TCGA are also presented. (E, F) OS of patients with IDH-wildtype LGGs according to the presence and absence of prognostic factors, including WHO grade (grade III) and co-occurrence of gain of chromosome 7p, loss of chromosome 10q, and TERT promoter mutation (pTERT) in the (E) JPN and (F) TCGA cohorts. For comparison, survival curves for patients with GBM, IDH-wildtype from the cohort from TCGA are also presented. P-values were calculated using the log-rank test.