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. 2017 Oct 20;159(1):414–425. doi: 10.1210/en.2017-00747

Figure 2.

Figure 2.

CRH has dose-dependent effects on firing activity of GnRH neurons from OVX+E mice. (A–C) Representative raw data from extracellular recordings of GnRH neurons during each period. (D) Firing rate of individual GnRH neurons during control (C), CRH treatment (CRH30 or CRH100), or vehicle treatment (Veh), and wash out (W) periods. Green and red lines indicate cells with ≥30% increase or decrease in firing frequency during treatment, respectively. *P < 0.05 mean firing frequency compared with control period, two-way repeated-measures ANOVA/Tukey. (E) Mean ± SEM percentage of control firing frequency; gray bars indicate wash after treatment. #P < 0.05 compared with control period, Friedman test/Dunn post hoc.