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. 2017 Oct 6;159(1):119–131. doi: 10.1210/en.2017-00565

Figure 2.

Figure 2.

Gonadotrope markers were unchanged by neonatal BPA exposure, despite regulation by E2. Gonadotrope marker Nr5a1 mRNA was measured in (a) males and (b) females at PND7, with no response to BPA. At 5 weeks, no effect of BPA or E2 was found in (c) males. (d) However, suppression of Nr5a1 mRNA expression was found in females with exposure to BPA0.05 and E2. Lhb mRNA was decreased by E2 in (e) males and (f) females at PND7 but (e) was unchanged by BPA. (g) At 5 weeks, Lhb was unaltered by any treatment group in males. (h) In females at 5 weeks, E2 caused substantial repression of Lhb mRNA. For PND7, n = 5 to 6; for 5 weeks, n = 3 to 6. Circles represent individual mice, and average is represented by a line. #P ≤ 0.05.