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. 2017 Oct 6;159(1):119–131. doi: 10.1210/en.2017-00565

Figure 3.

Figure 3.

BPA suppressed Pit1 mRNA at low doses in males but did not alter transcription of PIT1 lineage hormones. Pit1 mRNA was decreased at PND7 with 0.05 and 0.5 μg/kg/d BPA in (a) males but not (b) females. (c) However, PIT1 protein was not changed by BPA or E2 in males by western blot analysis. Prl mRNA was not altered by BPA but was increased with E2 in (d) males and (e) females. No difference was seen in Gh mRNA with any treatment in (f) males or (g) females. Also, no difference in Tshb mRNA with BPA or E2 exposure in (h) males or (i) females was detected. Pit1 mRNA at 5 weeks was not changed in (j) males or (k) females. For quantitative PCR, n = 3 to 6; for PND7 western blot, n = 3. Circles represent individual mice, and average is represented by a line. #P ≤ 0.05.