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. 2017 Nov 8;159(1):184–198. doi: 10.1210/en.2017-00677

Figure 2.

Figure 2.

Expression of Notch ligands and receptors is positively regulated by gonadotropins. Expression of Jag1, Jag2, Notch2, and Notch3 were quantified using qRT-PCR in samples collected after 48 hours of PMSG stimulation, followed by hCG stimulation for the times indicated. Data are presented as relative to Rpl19. Compared with unstimulated PND19 ovaries, Jag1 and Notch2 expression was transiently upregulated 4 to 12 hours post hCG stimulation. n = 10 for unstimulated samples, n = 5 for PMSG- and hCG-stimulated samples; *P < 0.05 compared with unstimulated. Modest upregulation of Notch3 was seen in luteinized ovaries (3 and 6 days post hCG), whereas Jag2 remained unchanged following exogenous gonadotropin stimulation.