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. 2018 Jan 10;38(2):308–321. doi: 10.1523/JNEUROSCI.2695-17.2017

Figure 1.

Figure 1.

Dose- and time-effect relationships for LMWH-induced mechanical hyperalgesia. Mechanical nociceptive threshold was evaluated before and 5, 10, 15, 20, and 30 min after intradermal injection of LMWH (0.1, 1, or 10 μg) on the dorsum of the hindpaw, in separate groups of rats. All three doses induced robust mechanical hyperalgesia (0.1 μg group: F(2.164,10.82) = 14.69, p = 0.0007; 1 μg group: F(2.366,11.83) = 38.95, p < 0.0001; 10 μg group: F(1.968,9.839) = 30.07, p < 0.0001) when the mechanical nociceptive threshold over time is compared with pre-LMWH injection baseline (repeated-measures ANOVA, followed by Bonferroni post hoc test). For the 0.1 μg dose, hyperalgesia was significant starting 15 min after injection (*p = 0.0062, when the mechanical threshold at this time point is compared with baseline). For the 1 and 10 μg doses, the hyperalgesia was already significant by 10 min (1 μg, ***p = 0.0010; 10 μg, **p = 0.0060). n = 6 paws per group.