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. 2018 Jan 10;38(2):379–397. doi: 10.1523/JNEUROSCI.2110-17.2017

Figure 4.

Figure 4.

Male DRD5KO mice exhibit thermal hypoalgesia. A, Thermal sensitivity is significantly impaired in male DRD5KO compared with WT mice in the Hargreaves test. N = 6–8 mice per group. B, Baseline thermal sensitivity is similar between female DRD5KO and WT mice in the Hargreaves test. N = 5–7 mice per group. C, Male DRD5KO show an increased tail-withdrawal latency compared with WT mice in the tail flick test at 49°C. N = 6 mice per group. D, No differences were observed in thermal sensitivity between female DRD5KO and WT. N = 6 mice per group. E, F, Motor skill learning and motor coordination are not impaired in male or female DRD5KO mice. N = 6–8 mice per group. **p < 0.01 (two-way ANOVA with Bonferroni post hoc test).