Figure 6.

Cocaine reverses escalated cocaine intake. A, Experimental timeline of 28 d of cocaine self-administration split into three epochs: (1) 14 d of self-administration with no treatment (initial escalation period), (2) 7 d of AMPH treatment during cocaine self-administration (treatment period), and (3) 7 d of self-administration after cessation of treatment (post-treatment period). B, Average infusions per day over the 28 d of self-administration. Dotted line indicates average intake across groups on day 1. Shaded area represents the AMPH treatment period. C, Cocaine intake was decreased by AMPH treatment during the treatment and post-treatment periods. Error bars indicate ± SEM. *p < 0.05 versus LgA+Saline. **p < 0.01 versus LgA+Saline. LgA+Saline, n = 5; LgA+AMPH, n = 5.