Figure 4.

RSN topography is disrupted and recovers during NMDAR encephalitis. Seed-based functional connectivity maps for healthy individuals (first column), Visit1 and Visit2. Seed regions for each network were posterior cingulate cortex (DMN), left frontal eye field (DAN), dorsal medial prefrontal cortex (CON), anterior cingulate (SAL), left primary motor cortex (SMN) and right primary visual cortex (VIS) indicated in white. Conventional functional connectivity was calculated between the seed region and all other voxels. Resulting correlations were Fisher z-transformed. $z\left(r\right)$ maps were thresholded voxel-wise $\left|z\left(r\right)\right|>0.2$ and only suprathreshold clusters consisting of more than 100 voxels are shown. Healthy individuals demonstrate focal and defined RSN topographies that are absent at Visit1 and restored at Visit2. Images are presented in radiologic convention.