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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Fertil Steril. 2018 Jan;109(1):20–26. doi: 10.1016/j.fertnstert.2017.10.028

Figure 1. Identification of candidate genes associated with susceptibility to male infertility and cancer.

Figure 1

Human homologs to mouse male infertility genes were intersected with a curated list of known cancer genes (the COSMIC “classic” list). The observed overlap of 25 genes is highly non-random: there is a five-fold enrichment of COSMIC cancer genes in the MGI male infertility list compared to genes that are not on the MGI list (4.7% versus 0.95%, OR=5.12, p< 5 × 10−10 by Fisher Exact Test). We further characterized these 25 candidates by their putative role in cancer. Vogelstein classification of cancer driver genes from (33).