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. Author manuscript; available in PMC: 2018 Feb 23.
Published in final edited form as: J Med Chem. 2017 Feb 13;60(4):1343–1361. doi: 10.1021/acs.jmedchem.6b01379

Scheme 12. Synthesis of compound 50f, an MBP analog of lead compound 35.

Scheme 12

(a) Meldrum’s acid, Triethylformate, 100 °C; (b) Dowtherm A, 250 °C; (c) POCl3, Toluene, 110 °C; (d) p-MBSH, NaH, DMF, 25 °C; (e) 2-(Thiazol-2-yl)ethan-1-amine, pyridine, EDC, HOBT, DMF, 25 °C; (f) m-Cresol, TFA, reflux.