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. Author manuscript; available in PMC: 2018 Feb 23.
Published in final edited form as: J Med Chem. 2017 Feb 13;60(4):1343–1361. doi: 10.1021/acs.jmedchem.6b01379

Scheme 3.

Scheme 3

(a) 2,2,6-Trimethyl-4H-1,3-dioxin-4-one (Meldrum’s acid), Triethyl orthoformate, 105 °C; (b) Dowtherm A, 250 °C; (c) POCl3, Toluene, 110 °C; (d) 4-Methoxyphenyl)methanethiol (p-MBSH), NaH, DMF, 25 °C; (e) m-Cresol, TFA, reflux.