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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Curr Opin Biomed Eng. 2017 Sep 22;4:1–12. doi: 10.1016/j.cobme.2017.09.002

Table 1.

Examples of nanocarriers loaded with therapeutic or imaging agents for CED

Nanocarrier Material Encapsulated agent Significant results Ref
Nanoparticle PLGA Camptothecin Improved median survival (22 days vs. 15 days) with 30% long-term survivors in 9L rat model [23]
PLGA Carboplatin Increased tumor cytotoxicity, reduced neurotoxicity, increased retention in rat and porcine models [24]
PLGA Dithiazanine iodide Brain-penetrating NPs inhibited growth of brain cancer stem cells and provided survival benefit in rats [12]
PEG-PLGA Paclitaxel PEGylated NPs provided enhanced distribution and tumor growth suppression in 9L rat model [30]
PEG-poly(aspartic acid) Cisplatin Reduced neurotoxicity of cisplatin with controlled release, and significantly enhanced survival (80% long-term survivors) [31]
Squalenoyl-PEG Gemcitabine PEGylated squalene NPs provided radiosensitization and survival benefit in RG2 rat model [32]
Poly(β-aminoester) HSV thymidine kinase DNA Achieved intratumoral transfection with and extended survival in 9L rat model [35]
PEG-poly-L-lysine DNA PEGylation of NPs improved distribution and efficient transfection in vivo [38]
Fe(Salen) - Combination with alternating magnetic field exposure provided greater anti-tumor effect (combined hyperthermia-chemotherapy) [41]
PLGA SPIO Enabled visualization of NP distribution in the rat brain by MRI, with long-lasting signal attenuation [49]
PEG-PLA-PCL Temozolomide, magnetite Multifunctional NPs were used to monitor NP distribution with MRI and prolonged survival of mice with U87 intracranial tumors [52]
Iron oxide EGFRvIII antibody Provided selective MRI contrast enhancement of tumor cells and targeted therapy in mouse model [101]
Liposome Dioleoyl lecithin, cholesterol, PEG2000 PE Gadolinium Enabled in vivo monitoring of complete tumor coverage and co-infusion with Doxil [46]
DSPC, cholesterol, PEG2000 PE Irinotecan Showed greater anti-tumor activity and survival benefit with CED of liposomal irinotecan plus radiation in mouse model [26]
DSPC, cholesterol Rhenium-186 Real-time visualization by SPECT; brachytherapy resulted in enhanced median survival (126 days vs. 49 days) in rat model [39]
DOPC, cholesterol, PEG-DSG Gadolinium CED and real-time MRI monitoring allowed visualization of distribution in non-human primate brain [47]
PEG-transferrin Sodium borocaptate, lomeprol Targeted boron to tumor tissue and enabled real-time CT imaging, with signal lasting over 72h [54]
Lipidoid telodendrimer Lipid-polymer hybrid Truncated diphtheria toxin Improved intratumoral distribution; achieved delivery of active proteins and tumor growth inhibition in mice with U87 tumors [29]
Lipid nanocapsule Chitosan siRNAs against Galectin-1 and EGFR Combination therapy of siRNA-LNCs and TMZ enhanced survival of mice with U87 tumors [36]
Lipoid Rhenium-188 Internal radiotherapy enhanced survival in mice witih orthotopic GBM tumors (50% long-term survivors) [40]
Nanodiamond Diamond Doxorubicin Enhanced DOX retention, localized toxicity and prolonged survival in rat model [27]
Micelle Poloxamer407 Panobinostat 100% survival after a single infusion in F89 rat model [28]
PEG-poly(glutamic acid) SN-38 Enhanced distribution and median survival in rat models, with minimal neurotoxicity [53]