Table I. Homologous relationships of mitochondrial fission and fusion factors in selected eukaryotes.
The table is reproduced and modified from Arimura and Tsutsumi (2016) with permission. IM, Inner membrane; OM, outer membrane. Dashes indicate that homologs are not present or not reported.
| Process | Organisms |
Features, Functions, and Localization (Estimated) | ||||
|---|---|---|---|---|---|---|
| Yeast S. cerevisiae | Mammal Homo sapiens | Seed Plant Arabidopsis | Liverwort M. polymorpha | Red alga C. merolae | ||
| Fission | Dnm1 | Drp1 | DRP3A, DRP3B | DRP3 | Dnm1 | Cytosolic, forming ring, GTPase |
| Fis1 | Fis1 | AtFIS1A, AtFIS1B | FIS1 | CMQ197C | OM, for localization of DRPs? (through Mdv1 in yeast) | |
| Mdv1, Caf4 | – | – | – | Mda1 | OM outer surface, interact with DRP and Fis1 (in yeast) | |
| – | Mff | – | – | – | OM, for localization of DRP to fission sites | |
| – | MiD49 and MiD51 | – | – | – | OM, for localization of DRP to fission sites | |
| – | – | ELM1, At5g06180 | ELM1 | – | OM outer surface, interact with DRP3 | |
| – | – | PMD1, PMD2 | – | – | OM, independent of DRP3, Rosidae specific | |
| – | – | – | – | FtsZ1 | Matrix, GTPase, polymerizes into ftsZ ring | |
| – | – | – | – | ZED | Matrix, bacterial cell division ZapA homolog, forms ring | |
| Fusion | Fzo1 | Mfn1, Mfn2 | – | – | – | OM, for OM fusion, GTPase |
| Mgm1 | Opa1 | – | – | – | IM and intermembrane space, for IM fusion, GTPase | |
| Ugo1 | – | – | – | – | OM, for OM fusion, interacts with Fzo1 and Mgm1, OM | |
| Clu1 | Clu | FMT | FMT | – | Cytosol and OM, deficiency causes clusters of mitochondria | |