Table 3. Inhibition of TSLP production by mTOR inhibitors everolimus and AZD8055.

Compound	Inhibition of TSLP protein production (IC50, μM) (95% CI) or % Inhibition ± SD at [μM]a	Inhibition of CHO viability at [3.12 μM] % Inhibition ± SD
Everolimus	79.4% ± 17.4 at 0.031 μM (n = 4)	-0.16% ± 2.3 (n = 4)
AZD8055	0.002 (0.0002–0.027) (n = 3)	20.47% ± 4.6 (n = 4)

Results shown as geometric mean IC₅₀ (95% confidence interval) or average % inhibition ± SD at the indicated concentration (n = number of replicates).

^a Results obtained using NHBE cells from donor #1.