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| Activity | Inhibition of indicated activity (IC50, μM) a |
|---|---|
| TSLP production (NHBE) | 0.075 b |
| PI3K (p110δ/p85α) | 0.233 |
| DNA-PK | 0.348 |
| MT3 (QR2) | 0.4 |
| PDE6 | 0.58 |
| PDE5 | 0.92 |
| mTOR | 0.964 |
| Yes | 2.386 |
| Ftl4 | 3.132 |
| TrkA | 3.232 |
| Hck | 3.581 |
| Lck | 3.330 |
| PI3K (p120γ) | 4.782 |
a Except for TSLP, all IC50 activities are based on biochemical assays dose response curves with duplicate determinations for each concentration.
b Activity as indicated in Fig 5.
