Table 2. Number of germline and somatic variants identified in three mesothelioma samples using whole genome sequencing.
SNV | Indels | ||||||||
---|---|---|---|---|---|---|---|---|---|
9869 | 11202 | 11398 | All Patients | 9869 | 11202 | 11398 | All Patients | ||
Germline | Identified in both platforms | 3,033,980 | 3,146,317 | 3,092,543 | 9,272,840 | 193,359 | 190,436 | 185,905 | 569,700 |
(96.8%) | (96.8%) | (96.8%) | (96.8%) | (91.7%) | (91.8%) | (92%) | (91.8%) | ||
HiSeq X Ten only | 313,015 | 321,627 | 407,966 | 1,042,608 | 33,143 | 35,253 | 41,480 | 109,876 | |
(42.3%) | (42.3%) | (41.9%) | (42.1%) | (58.5%) | (58.4%) | (59.2%) | (58.7%) | ||
BGISEQ-500 only | 161,128 | 118,336 | 92,050 | 371,514 | 7,025 | 6,931 | 5,789 | 19,745 | |
(4%) | (2.4%) | (4.1%) | (3.55%) | (13.8%) | (13.8%) | (11.6%) | (13.1%) | ||
Total | 3,508,123 | 3,586,280 | 3,592,559 | 10,686,962 | 233,527 | 232,620 | 233,174 | 699,321 | |
Somatic | Identified in both platforms | 3,554 | 2,342 | 1,955 | 7,851 | 197 | 168 | 114 | 479 |
HiSeq X Ten only | 697 | 424 | 411 | 1,532 | 135 | 93 | 78 | 306 | |
BGISEQ-500 only | 540 | 474 | 493 | 1,507 | 102 | 156 | 229 | 487 | |
Total | 4,791 | 3,240 | 2,859 | 10,890 | 434 | 417 | 421 | 1,272 |