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Activated pro-apoptotic caspases are expressed throughout the growth plate of developing long bones. Hematoxylin–eosin and Alcian blue staining of the growth plate (A), immunohistochemical detection of individual caspases in resting, proliferation, hypertrophic, and ossification zones of the growth plate: caspase-3 (B, C, D, E), caspase-6 (F, G, H, I), caspase-7 (J, K, L, M), caspase-8 (N, O, P, Q), and caspase-9 (R, S, T, U). Arrows point to positive cells (brown). Scale bar = 50 µm.
