Table 1.
Mortality of Patients in Interventional Trials of Intensive Insulin Therapy, Stratified by Diabetes Status.
| Conventional arm |
Interventional arm |
RR for mortality: interventional arm* |
||||
|---|---|---|---|---|---|---|
| No diabetes | Diabetes | No diabetes | Diabetes | No diabetes | Diabetes | |
| Leuven 1 (Van den Berghe et al)1 | 57/680 (8.4%) | 6/103 (5.8) | 31/664 (4.7%) | 4/101 (4.0%) | 0.56 (0.36-0.85)a | 0.68 (0.20-2.33)b |
| Leuven 2 (Van den Berghe et al)3 | 208/508 (40.9%) | 34/97 (35.1%) | 180/409 (36.8%) | 42/106 (39.6%) | 0.90 (0.77-1.05)c | 1.13 (0.79-1.62)d |
| Stamford (Krinsley)2** | 399/2134 (18.7%) | 120/532 (22.6%) | 287/2121 (13.5%) | 111/578 (19.2%) | 0.72 (0.63-0.83)e | 0.85 (0.67-1/07)f |
| NICE-SUGAR (NICE-SUGAR Study Investigators)6 | 586/2416 (24.3%) | 165/596 (27.7%) | 634/2394 (26.5%) | 195/615 (31.7%) | 1.09 (0.99-1.20)g | 1.15 (0.96-1.36)h |
*
Relative risk and 95% CI. **Before and after nonrandomized trial. The other studies listed were RCTs.
a
P = .0068. bP = .5403. cP = .1815. dP = .5029. eP < .0001. fP = .1698. gP = .0760. hP = .1265.