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The human IgG1 heavy chain contains several methionine residues (M252, M358, and M428) that are prone to oxidation. A, Model of the IgG1 constant fragment with oxidizable Met residues circled on 1 chain of the dimer. The 2 most reactive residues, M252 and M428, are found in close proximity, located at the CH2–CH3 domain interface. Image was produced with MOE software using the available human IgG1 structure deposited within the protein data bank (accession 1FC1).
