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. 2017 Nov 22;16(6):1209–1219. doi: 10.1177/1533034617742312

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — The related protein expressions and cell migration and invasion. A, Western blot assays show that IL-6 induces p-STAT3 activation on the 2 cell lines, E-cadherin downexpressed, and vimentin, Twist upexpressed. And AG490 inhibit p-STAT3 activation on the 2 cell lines, E-cadherin upexpressed, and vimentin, Twist downexpressed. B and C, Transwell assays were performed in the cell lines to indicate that p-STAT3 activation could affect migration and invasion (magnification, ×100). B, The migration and invasion abilities of HCT116 and HT29 cells were increased following the induction of IL-6. C, The migration and invasion abilities of HCT116 and HT29 cells were decreased following AG490 treatment.