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. 2017 Nov 22;16(6):1209–1219. doi: 10.1177/1533034617742312

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — p-STAT3 activation promotes vasculogenic mimicry (VM) by inducing vimentin. A, 3-D culture assays suggested that p-STAT3 activation has positive influence on the VM (magnification, ×200). Interleukin 6 (IL6)-induced HCT116 form more vascular structures than control, and HT29 cells have a trend to form a tube-like structure. AG490-inhibited HCT116 form less vascular structures than control. B, Western blot assays show that IL-6 induces p-STAT3 activation and VM marker VE-cadherin upexpressed; AG490 inhibits p-STAT3 activation and VE-cadherin downexpressed. C, Immunofluorescence double staining assays indicated that p-STAT3 activation may induce VM formation by inducing epithelial-to-mesenchymal transition (EMT) marker vimentin, not directly affecting on VM marker VE-cadherin (magnification, ×100).