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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Biomaterials. 2017 Sep 17;148:16–30. doi: 10.1016/j.biomaterials.2017.09.017

Fig. 5. sHDL nanodisc platform for cancer vaccine.

Fig. 5

(A) sHDL nanodiscs, composed of phospholipids and apolipoprotein-1 mimetic peptides, are engineered for co-delivery of antigen (Ag) peptides and cholesterol-modified immunostimulatory molecules (Cho-CpG). (B) Fluorescence signals in the draining inguinal lymph nodes at 24 hours after subcutaneously administration of 31 nmol FITC-tagged Ag in free form or sHDL form. (C) The frequency of neoantigen Adpgk-specific CD8+ T cells in peripheral blood of C57BL/6 mice after vaccination three times with the indicated formulations (equivalent to 15.5 nmol mutated Adpgk peptide and 2.3 nmol CpG) in a biweekly interval. Adapted by permission from Macmillan Publishers Ltd: [Nature Materials] [106], copyright (2016).