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. Author manuscript; available in PMC: 2018 Jan 10.
Published in final edited form as: Adv Exp Med Biol. 2017;1033:225–247. doi: 10.1007/978-3-319-66653-2_11

Fig 4. Model of Probiotic mechanistic signals regulating bone density.

Fig 4

A disruption in gut microbiota homeostasis can lead to increased inflammation and gut permeability resulting in systemic organ inflammation, including within bone. Prevention of local gut inflammation and permeability by promoting a healthy gut microflora (eubiosis) is one of the many ways probiotics can benefit bone health.