Table 3.
NAC, Cys, and GSH PK parameters using non-compartmental analysis for a single dose (3000 mg) of NAC at steady-state
| PD (n=4) | HC (n=3) | ||||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| PK Parameter | Mean | SD | CV% | Mean | SD | CV% | |
| NAC | Tmax (min) | 82.5 | 15.0 | 18 | 90 | 34.6 | 27 |
| Cmin (μg/mL) | 0.20 | 0.36 | 17 | 1.4 | 0.45 | 26 | |
| Cmax (μg/mL) | 11.0 | 3.1 | 28 | 7.3 | 2.7 | 37 | |
| AUC(0–6) (μg*min/mL) | 2111 | 453 | 21 | 1690 | 336 | 20 | |
| t1/2 (hr) | 4.6 | 3.3 | 73 | 5.9 | 3.6 | 62 | |
|
| |||||||
| Cys | Tmax (min) | 60 | 34.6 | 58 | 70 | 17.3 | 25 |
| Cmin (μg/mL) | 5.0 | 2.9 | 58 | 6.6 | 8.7 | 130 | |
| Cmax (μg/mL) | 15.1 | 8.81 | 58 | 25.7 | 5.0 | 20 | |
| AUC(0–6) (μg*min/mL) | 2537 | 1625 | 64 | 5139 | 3880 | 75 | |
|
| |||||||
| GSH | Tmax (min) | 40 | 45.8 | 115 | 105 | 135 | 129 |
| Cmin (μg/mL) | 0.81 | 0.10 | 13 | 0.36 | 0.37 | 102 | |
| Cmax (μg/mL) | 1.30 | 0.44 | 28 | 0.92 | 0.20 | 22 | |
| AUC(0–6) (μg*min/mL) | 302 | 33.2 | 11 | 187 | 114 | 61 | |