. Author manuscript; available in PMC: 2019 Feb 1.

Published in final edited form as: J Clin Pharmacol. 2017 Sep 22;58(2):158–167. doi: 10.1002/jcph.1008

Table 4.

Compartmental pharmacokinetic parameter estimates for total NAC following a single dose (3000 mg) of NAC at steady-state

	Param. Estimate	RSE%	IIV	RSE%

Dose (mg/kg)

Ka (hr⁻¹)	0.79	33	^a	^a
V/F (L)	269	30	40%	49
CL/F (L/hr)	66.6	6.5	12%	6.7

RUV	18%	20 (CV%)

: unable to estimate due to high shrinkage (>40%)

Ka: absorption rate constant, V: volume of distribution, F: oral bioavailability, CL: steady-state clearance, RUV: random unexplained variability, RSE: relative standard error, IIV: inter-individual variability