Table 2.
Association of baseline covariates with any confirmed decline in CrCl <60 mL/min
| Adjusted hazard ratios comparing those with the characteristic to those without** (95% CI); p= values |
|||||
|---|---|---|---|---|---|
|
| |||||
| Baseline characteristic |
Unconfirmed CrCl <60 mL/min, %* |
ǂConfirmed CrCl <60 mL/min, %* |
Overall |
For events occurring within 12 months of PrEP initiation |
|
| Sex | |||||
| Female (n=1956) | 7.6% | 1.9% | 1.92 (0.97, 3.79); p=0.06 | 6.57 (1.85, 23.30); p=0.004 | |
| Male (n=3402) | 1.1% | 0.4% | |||
|
| |||||
| Age ― years | |||||
| ≥45 (n=676) | 9.9% | 3.4% | 3.18 (1.76, 5.75); p<0.001 | 2.66 (1.23, 5.73); p=0.01 | |
| <45 (n=4682) | 2.5% | 0.6% | |||
|
| |||||
| Weight ― kg | |||||
| ≤55 (n=1601) | 6.3% | 1.9% | 2.01 (1.13, 3.57); p=0.017 | 1.63 (0.78, 3.38); p=0.19 | |
| >55 (3757) | 2.3% | 0.6% | |||
|
| |||||
| Systolic blood pressure ― mmHg | |||||
| ≥140 (n=274) | 2.55% | 1.8% | 2.57 (0.98, 6.78); p=0.06 | 2.47 (0.56, 10.95); p=0.23 | |
| <140 (n=5084) | 3.5% | 0.9% | |||
|
| |||||
| CrCl ― mL/min | |||||
| 60–90 (n=1105) | 14.7% | 4.3% | 22.50 (7.78, 65.07); p<0.001 | 44.11 (5.84, 333.27); p<0.001 | |
| >90 (n=4253) | 0.6% | 0.1% | |||
*
Row percent
**
Cox regression model stratified by site.
ǂ
Abnormal testing confirmedon repeat measurement, mostly done within 1 week.