Table 3.
Trimester-specific association of antibiotic or antifungal use with body mass index (BMI) Z-score and child overweight/obese at age 2 year visit; evidence for a trimester-specific effect is indicated with the interaction P term
| BMI Z-score | Overweight/Obese | |||
|---|---|---|---|---|
| Model 1 | Model 2 | Model 1 | Model 2 | |
| Antibiotic Use | β±se (P) | β±se (P) | OR (95 % CI OR) (P) | OR (95 % CI OR) (P) |
| 1st trimester | 0.23±0.11 (P=0.043) | 0.21±0.12 (P=0.071) | 1.71 (1.05, 2.77) (P=0.032) | 1.78 (1.07, 2.98) (P=0.028) |
| 2nd trimester | 0.24±0.12 (P=0.05) | 0.28±0.13 (P=0.028) | 1.44 (0.85, 2.45) (P=0.175) | 1.34 (0.74, 2.46) (P=0.337) |
| 3rd trimester | −0.001±0.10 (P=0.990) | −0.04±0.10 (P=0.691) | 0.74 (0.45, 1.21) (P=0.234) | 0.72 (0.42, 1.22) (P=0.225) |
| Interaction P | 0.070 | 0.032 | 0.094 | 0.098 |
| Antifungal Use | β±se (P) | β±se (P) | OR (95 % CI OR) (P) | OR (95 % CI OR) (P) |
| 1st trimester | 0.35±0.21 (P=0.090) | 0.02±0.22 (P=0.915) | 1.18 (0.47, 2.96) (P=0.729) | 0.63 (0.22, 1.85) (P=0.403) |
| 2nd trimester | −0.02±0.20 (P=0.907) | −0.08±0.20 (P=0.687) | 1.23 (0.52, 2.91) (P=0.635) | 1.18 (0.48, 2.89) (P=0.714) |
| 3rd trimester | −0.10±0.18 (P=0.560) | −0.23±0.18 (P=0.201) | 0.89 (0.38, 2.05) (P=0.777) | 0.88 (0.40, 1.96) (P=0.763) |
| Interaction P | 0.221 | 0.578 | 0.943 | 0.787 |
Model 1: Unadjusted; Model 2: adjusted for infant gender, delivery mode, ever breastfed, maternal age, maternal race, maternal education, birthweight Z-score, child age at 2-year visit and BMI at first prenatal care visit