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. 2017 Nov 18;8(67):110743–110755. doi: 10.18632/oncotarget.22500

Figure 4. Synergistic effect of SI113 plus VCR, and SI113 plus EPO-A in restraining the growth of the ADF cells: Clonogenic Assay.

Figure 4

(A) ADF cells were exposed to solvent(s) (Control), 8.5 µM SI113, 0.312 nM VCR or their association for 48 h and then allowed to grow and form colonies for the subsequent 12 d. Cell colonies, after staining with crystal violet (upper panels), were counted and the values reported as percent colony number in the histogram (lower panel). Statistical significance is also indicated (*significance vs. Control; ^significance vs. SI113; §significance vs. VCR). (B) As in panel A, except for the use of 0.5 nM EPO-A as the companion drug. Statistical significance is also indicated (*significance vs. Control; ^significance vs. SI113; §significance vs. EPO-A).