Table 2. Comparison of metabolic changes with metformin treatment in the ovarian tumors from obese and lean KpB mice.

Sub-Pathway	Biochemical Name	Lean-Met/Lean-Ctrl*	Obese-Met/Obese-Ctrl*
Glycolysis	Glucose	2.75	0.46
	Glucose-6-phosphate	0.91	1.82
	Fructose-6-phosphate	0.87	2.3
	Fructose-1-6-bisphosphate	0.68	2.4
	2,3-diphosphoglycerate	1.34	13.86
	Dihydroxyacetone phosphate	0.64	2.44
	Phosphoenolpyruvate	2.99	1.7
	Pyruvate	0.27	1.36
	Lactate	0.82	1.35
TCA Cycle	Citrate	0.46	0.94
	Alpha-ketoglutarate	1.23	1.53
	Succinylcarnitine	3.6	2.44
	Succinate	3.29	0.22
	Fumarate	0.73	1.57
	Malate	0.8	1.4
Glutamine	α-ketoglutarate	1.23	1.53
Oxidation	Glucosamine-6-phosphate	0.65	1.8
	N-acetylglucosamine-6-phosphate	0.56	2.13
n3 and n6	Eicosapentaenoate	0.54	1.12
Fatty Acids	Docosapentaenoate	0.48	1.94
	Docosahexaenoate	0.69	1.97
	Dihomo-linolenate	0.99	2.23
	Arachidonate	0.90	2.28
	Adrenate	0.51	2.1
	Docosapentaenoate	0.72	3.75
	Docosadienoate	0.57	1.83
Lysolipids	1-arachidonoylglycerophophocholine	1.5	2.6
	1-palmitoylplasmenylethanolamine	0.82	3.24
	1-stearoylplasmenylethanolamine	0.96	3.38
	1-oleoylplasmenylethanolamine	0.72	2.82
	1-palmitoylglycerophosphoethanolamine	0.87	3.0
	1-stearoylglycerophosphoethanolamine	0.72	2.21
	2-stearoylglycerophosphoethanolamine	0.57	2.68
	1-oleoylglycerophosphoethanolamine	1.18	2.72
	1-palmitoylglycerophosphoinositol	1.16	4.71
	1-stearoylglycerophosphoinositol	0.86	2.8
	1-arachidonoylglycerophosphoinositol	0.23	2.64
	1-stearoylglycerophosphoserine	2.15	2.5
	1-oleoylglycerophosphoserine	1.88	3.15

*dark green and red = p<0.05, light green and pink = p<0.1.