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. 2017 Nov 15;8(67):111110–111118. doi: 10.18632/oncotarget.22624

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Copyright: © 2017 Yu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) IC₅₀ determination of CHMFL-KIT-031 with purified KIT wt/V559D kinase protein using the ADP-Glo assay method. (B) Kd determination of CHMFL-KIT-031 with purified KIT wt/V559D kinase protein using the MST technology. (C) In cell EC₅₀ determination of CHMFL-KIT-031 with parental Colo320DM (KIT wt) and KIT V559D overexpressed Colo320DM cells. (D) Effect of CHMFL-KIT-031 on KIT mediated signaling pathways in BaF3-TEL-KIT-V559D cells.