Table 6. Univariate and multivariate Cox proportional hazard analysis of overall survival in CRC.
| Variables | n | OS | |||
|---|---|---|---|---|---|
| Univariate | Multivariate | ||||
| HR (95%CI) | p | HR (95%CI) | p | ||
| Age | 0.208 | 0.064 | |||
| <60 | 39 | 1.00 | 1.00 | ||
| ≥60 | 63 | 1.58 (0.77-3.26) | 2.1 (0.96-4.61) | ||
| Sex | 0.796 | 0.753 | |||
| Male | 47 | 1.00 | 1.00 | ||
| Female | 55 | 1.09 (0.55-2.16) | 1.13 (0.53-2.42) | ||
| Tumor site | 0.352 | 0.067 | |||
| Colon | 65 | 1.00 | 1.00 | ||
| Rectum | 37 | 1.39 (0.69-2.78) | 2.12 (0.95-4.71) | ||
| Differentiation | 0.011 | 0.638 | |||
| Moderate-Well | 39 | 1.00 | 1.00 | ||
| Poor | 61 | 2.44 (1.23-4.86) | 1.25 (0.49-3.24) | ||
| TNM | 0.001 | 0.002 | |||
| I-II | 41 | 1.00 | 1.00 | ||
| III-IV | 59 | 2.33(1.44-3.76) | 2.44 (1.38-4.30) | ||
| LVI | 0.007 | 0.043 | |||
| No | 67 | 1.00 | 1.00 | ||
| Yes | 32 | 2.57 (1.30-5.10) | 2.33 (1.03-5.30) | ||
| Tumor size | 0.327 | 0.012 | |||
| <5cm | 53 | 1.00 | 1.00 | ||
| ≥ 5cm | 48 | 1.42 (0.71-2.84) | 2.81 (1.25-6.3) | ||
| RIP140 | 0.073 | 0.034 | |||
| Low | 44 | 1.00 | 1.00 | ||
| Mod-High | 58 | 0.58 (0.32-1.05) | 0.51 (0.28-0.95) | ||
| LCoR | 0.416 | 0.103 | |||
| Low | 70 | 1.00 | 1.00 | ||
| Mod-High | 29 | 1.17 (0.8-1.72) | 1.41 (0.93-2.12) | ||
Abbreviations: OS, overall survival; HR, hazard ratio; CI, confidence interval; CRC, colorectal cancer; LVI, lympho vascular invasion.