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. 2017 Nov 27;8(67):111213–111224. doi: 10.18632/oncotarget.22740

Figure 7. PAA prevents tumor growth in an iron-dependnet manner in MM.

Figure 7

(A) Xenografted NOD.Cγ -Rag1 mice (n=5/group) were treated with PAA alone and in combination with DFO. After one-week injection of ARP1 cells, mice were treated with either PAA (4mg/kg) injected intraperitoneal once a day, 5 days every week for 3 weeks. DFO (100 mg/kg) was injected intraperitoneal once a day, 2 days a week for 3 weeks. (B) Total flux of mice described in A indicates quantification of luciferase intensity (tumor burden) of mice pre- and post treatment at different time points. #No significance, *p < 0.05, *** p < 0.001. (C) Another MM mouse model injected ARP1 intraperitoneally and treated with PAA was used and analyzed, tumors were dissected at week 3 after PAA treatment from each mouse. Tumor size was measured (right graph bar).