Table 2. Plasma pharmacokinetic parameters of DEX-SS-IND/PTX (10 mg/kg PTX) micelles.
| PTX | DEX-IND/PTX | DEX-SS-IND/PTX | |
|---|---|---|---|
| t1/2α/h | 1.07 ± 0.34 | 1.85 ± 0.09 | 2.05 ± 0.38* |
| t1/2β/h | 5.26 ± 1.84 | 9.76 ± 2.80 | 9.99 ± 2.37 |
| MRT0-∞/h | 5.14 ± 1.15 | 10.23 ± 1.56 | 8.46 ± 2.59 |
| AUC0-∞/μg·mL-1·h-1 | 820.84 ± 95.36 | 4364.08 ± 1715.46 | 3575.57 ± 1507.98 |
| Cmax/μg·mL-1 | 29.70 ± 2.66 | 52.40 ± 5.37 | 52.23 ± 3.60 |
| CL/mL·h-1·kg-1 | 8.58 ± 1.47 | 2.19 ± 1.28 | 3.06 ± 1.29* |
| Vd/mL·kg-1 | 67.47 ± 9.17 | 29.30 ± 4.20 | 28.40 ± 4.18* |
t1/2, half-life; Cmax, peak concentration; AUC, area under the concentration-time curve; MRT, mean residence time; CL, clearance rate; Vd, apparent volume of distribution.