Table 1. Patient characteristics.
| Factor | Treatment | |||
|---|---|---|---|---|
| With early RT (n=49) (%) | Without early RT (n=64) | |||
| EGFR-TKI alone (n=37) (%) | With salvage RT (n=27) (%) | P value | ||
| Age (year) | 0.272 | |||
| ≤60 | 33(67) | 26(70) | 14(52) | |
| >60 | 16(33) | 11(30) | 13(48) | |
| Median(range) | 54(35-80) | 56(29-73) | 59(33-75) | |
| Sex | 0.527 | |||
| Female | 30(61) | 24(65) | 20(74) | |
| Male | 19(39) | 13(35) | 7(26) | |
| ECOG performance status | 0.132 | |||
| 0-1 | 37(75) | 34(92) | 21(78) | |
| ≥2 | 12(25) | 3(8) | 6(22) | |
| Symptomatic from BM | <0.001 | |||
| No | 10(20) | 32(87) | 18(67) | |
| Yes | 39(80) | 5(13) | 9(33) | |
| Number of BMs | 0.162 | |||
| ≤3 | 12(25) | 4(11) | 3(11) | |
| >3 | 37(75) | 33(89) | 24(89) | |
| DS-GPA | 0.001 | |||
| 0-2.0 | 42(86) | 19(51) | 22(81) | |
| 2.5-4.0 | 7(14) | 18(49) | 5(19) | |
| Brain radiation | 0.550 | |||
| WBRT | 37(76) | - | 22(81) | |
| SRS | 12(24) | - | 5(19) | |
| Smoking status | 0.606 | |||
| Never or light smoker | 37(76) | 30(81) | 19(70) | |
| Heavy smoker | 12(24) | 7(19) | 8(30) | |
| EGFR mutations | 0.222 | |||
| 19-del | 20(41) | 17(46) | 9(33) | |
| L858R | 19(39) | 18(49) | 15(56) | |
| Unknown | 10(20) | 2(5) | 3(11) | |
Abbreviations: EGFR=epidermal growth factor receptor; TKI=tyrosine kinase inhibitor; BM=brain metastasis; DS-GPA= Disease-specific Graded Prognostic Assessment; ECOG=Eastern Cooperative Oncology Group; WBRT= whole brain radiotherapy; SRS= stereotactic radiosurgery; Never smoker= patient who had smoked less than 100 cigarettes during their lifetime; Light smoker=patient who had smoked less than 10 packs a year.