Table 3. Genetic relationship between TNF-α rs361525 and sepsis risk.
| Comparison | Subgroup | Sample size | Association test | |||
|---|---|---|---|---|---|---|
| Studies | Case/control | z | Passociation | OR (95% CI) | ||
| A vs. G | overall | 9 | 1,916/3,372 | 1.82 | 0.069 | - |
| PB | 5 | 1,214/1,182 | 3.20 | 0.001 | 1.52 (1.18–1.97) | |
| HB | 3 | 382/1,018 | 0.56 | 0.574 | - | |
| Caucasian | 4 | 904/2,413 | 0.49 | 0.622 | - | |
| Asian | 4 | 975/845 | 2.68 | 0.007 | 1.52 (1.12–2.05) | |
| Severe sepsis | 5 | 817/2,749 | 0.17 | 0.863 | - | |
| Septic shock | 4 | 404/2,148 | 1.33 | 0.183 | - | |
| AA vs. GG | overall | 6 | 961/2,552 | 3.42 | 0.001 | 4.24 (1.85–9.69) |
| PB | 3 | 296/476 | 1.90 | 0.058 | - | |
| HB | 2 | 345/904 | 1.96 | 0.050 | - | |
| Caucasian | 4 | 904/2,413 | 2.86 | 0.004 | 3.81 (1.52–9.52) | |
| Asian | 2 | 57/139 | 1.89 | 0.059 | - | |
| Severe sepsis | 3 | 352/2,037 | 2.14 | 0.032 | 3.51 (1.11–11.05) | |
| Septic shock | 4 | 404/2,148 | 2.89 | 0.004 | 4.50 (1.62–12.51) | |
| GA vs. GG | overall | 9 | 1,916/3,372 | 0.53 | 0.595 | - |
| PB | 5 | 1,214/1,182 | 2.77 | 0.006 | 1.46 (1.12–1.91) | |
| HB | 3 | 382/1,018 | 1.66 | 0.098 | - | |
| Caucasian | 4 | 904/2,413 | 0.80 | 0.423 | - | |
| Asian | 4 | 975/845 | 2.25 | 0.024 | 1.44 (1.05–1.98) | |
| Severe sepsis | 5 | 817/2,749 | 0.95 | 0.342 | - | |
| Septic shock | 4 | 404/2,148 | 0.02 | 0.985 | - | |
| GA+AA vs. GG | overall | 9 | 1,916/3,372 | 1.17 | 0.243 | - |
| PB | 5 | 1,214/1,182 | 3.01 | 0.003 | 1.51 (1.15–1.97) | |
| HB | 3 | 382/1,018 | 1.14 | 0.254 | - | |
| Caucasian | 4 | 904/2,413 | 0.18 | 0.858 | - | |
| Asian | 4 | 975/845 | 2.49 | 0.013 | 1.49 (1.09–2.05) | |
| Severe sepsis | 5 | 817/2,749 | 0.59 | 0.558 | - | |
| Septic shock | 4 | 404/2,148 | 0.64 | 0.519 | - | |
| AA vs. GG+GA | overall | 6 | 961/2,552 | 3.41 | 0.001 | 4.24(1.85–9.72) |
| PB | 3 | 296/476 | 1.83 | 0.068 | - | |
| HB | 2 | 345/904 | 1.99 | 0.046 | 3.35 (1.02–10.99) | |
| Caucasian | 4 | 904/2,413 | 2.88 | 0.004 | 3.87 (1.54–9.69) | |
| Asian | 2 | 57/139 | 1.82 | 0.069 | - | |
| Severe sepsis | 3 | 352/2,037 | 2.19 | 0.029 | 3.63 (1.14–11.50) | |
| Septic shock | 4 | 404/2,148 | 2.85 | 0.004 | 4.45 (1.59–12.41) | |
| carrier A vs. carrier G | overall | 9 | 1,916/3,372 | 1.14 | 0.254 | - |
| PB | 5 | 1,214/1,182 | 2.73 | 0.006 | 1.45 (1.11–1.89) | |
| HB | 3 | 382/1,018 | 0.95 | 0.342 | - | |
| Caucasian | 4 | 904/2,413 | 0.07 | 0.948 | - | |
| Asian | 4 | 975/845 | 2.27 | 0.023 | 1.44 (1.05–1.97) | |
| Severe sepsis | 5 | 817/2,749 | 0.45 | 0.653 | - | |
| Septic shock | 4 | 404/2,148 | 0.65 | 0.517 | - | |
PB: population-based control; HB: hospital-based control; OR: odd ratio; CI: confidence interval; -: ORs (95% CIs) not provided for Passociation >0.05.