Figure 7. Anti-myeloma activity of YM155 in vivo.

NOD/SCID mice were inoculated subcutaneously with 1.7 × 10⁷ cells of RPMI8226 into the flank. Mice were treated with 5mg/kg of YM155 intraperitoneally once daily for 9 days (n = 6) or the vehicle (Control) on the same schedule (n = 6). Caliper measurements of the longest perpendicular tumor diameters were performed as described in materials and methods. ^*P<0.05, ^**P<0.01.