Figure 1. High glucose promotes the migration and invasiveness of TSCC in vitro.

(A-C) Compared with normal glucose (5.6mM), high glucose (11.1mM, 16.7mM or 25.0mM) significantly promoted the migration (A), invasion (B) and proliferation (C) of UM1 cells in a concentration - dependent manner. (D) The protein levels of PKM2, SOD2, Vimentin, Slug and pERK1/2 were obvious increased in UM1 cells cultured with high glucose (11.1mM, 16.7mM or 25.0mM), but the protein level of E-cadherin was decreased. SOD2 activity (E) and H₂O₂ production (F) were significantly increased in UM1 cells cultured with high glucose (11.1mM, 16.7mM or 25.0mM). ^*P<0.05 compared with UM1 cells cultured with 5.6mM glucose.