Table 2. Univariate Analysis for Overall Survival (OS) in patients with localized osteosarcoma.
| Pts N. | % 5-year OS | 95% CI | P-value | |
|---|---|---|---|---|
| Overall | 86 | 74.5 | 65-84 | |
| Age | 0.9 | |||
| ≥ 18 years | 27 | 74 | 57-90 | |
| < 18 years | 59 | 75 | 63-86 | |
| Sex | 0.8 | |||
| Female | 33 | 76 | 61-90 | |
| Male | 53 | 74 | 61-89 | |
| Histologic Response° | 0.0001 | |||
| Good | 45 | 89 | 80-98 | |
| Poor | 40 | 57 | 42-73 | |
| CD8 | 0.003 | |||
| Positive | 74 | 78 | 69-88 | |
| Negative | 12 | 50 | 22-78 | |
| TIA-1 °° | 0.008 | |||
| Moderate | 14 | 86 | 67-100 | |
| Focal | 43 | 79 | 67-91 | |
| None | 21 | 52 | 31-74 | |
| CD8/ Tia1 °° | 0.002 | |||
| Positive / Positive | 57 | 81 | 70-91 | |
| Positive / Negative | 10 | 60 | 30-90 | |
| Negative / Negative | 11 | 45 | 16-75 | |
| CD3 | 0.07 | |||
| Positive | 77 | 78 | 69-87 | |
| Negative | 9 | 44 | 12-77 | |
| FOXP3 * | 0.13 | |||
| Positive | 28 | 75 | 54-93 | |
| Negative | 56 | 73 | 64-85 | |
| PD-1 (IC) | 0.6 | |||
| Positive | 19 | 74 | 54-93 | |
| Negative | 67 | 74 | 64-85 | |
| PD-L1 (IC) | 0.14 | |||
| Positive | 12 | 58 | 30-86 | |
| Negative | 74 | 77 | 67-87 | |
| LDH °° | 0.15 | |||
| Normal | 60 | 78 | 68-89 | |
| High | 18 | 61 | 39-84 | |
| sAP | 0.04 | |||
| Normal | 48 | 85 | 75-95 | |
| High | 38 | 64 | 48-80 | |
| Arginase-1 ** | 0.3 | |||
| Positive | 16 | 81 | 62-100 | |
| Negative | 61 | 70 | 59-82 | |
| CD303 °° | 0.9 | |||
| Positive | 3 | 67 | 13-100 | |
| Negative | 75 | 73 | 63-83 | |
| CD68 * | 0.1 | |||
| High | 31 | 84 | 71-99 | |
| Low | 53 | 67 | 54-80 | |
| CD163 *** | 0.17 | |||
| Positive | 47 | 81 | 70-92 | |
| Negative | 23 | 56 | 36-77 |
° Not available in 1 patient; °° non available in 8 patients; * not available in 2 patients; ** not available in 7 patients; *** not available in 16 patients