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. 2017 Dec 5;8(67):111866–111881. doi: 10.18632/oncotarget.22942

Table 1. List of validated genes that are hypomethylated and upregulated in liver cancer cells as compared with primary liver cells and were downregulated by SAM (log2FC-log2 fold change).

Gene Log2FC SAM/untreated Description Pathway
SKhep1 unique(Metastasis-related)
DDIT3 -1.76 DNA-damage-inducible transcript 3 MAPK signaling pathway,
MIA -1.17 Melanoma Inhibitory Activity MIA pathway
TAF15 -1.08 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor Assembly of RNA Polymerase II Complex; Estrogen Receptor Signaling
MTHF2 -0.80 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase Glyoxylate and dicarboxylate metabolism, One carbon pool by folate,
ITGA6 -0.72 integrin, alpha 6 Focal adhesion, ECM-receptor interaction,……
NFIB -0.72 nuclear factor I/B
PBK -0.67 PDZ binding kinase
PDK1 -0.61 pyruvate dehydrogenase kinase, isozyme 1 T cell receptor signaling pathway, Fc epsilon RI signaling pathway, …..
CLIC4 -0.56 chloride intracellular channel 4
SLC2A1 -0.40 solute carrier family 2 (facilitated glucose transporter), member 1 Pathways in cancer, Renal cell carcinoma,….
STMN1 -0.35 stathmin 1 MAPK signaling pathway,
SKhep1 and HepG2 common (proliferation related)
NFIL3 -0.49 nuclear factor, interleukin 3 regulated
RAN -0.63 RAN, member of RAS oncogene family Mechanism of Protein Import into the Sumoylation by RanBP2 Regulates Transcriptional Repression,……
TRIB3 -0.78 tribbles homolog 3 (Drosophila)
PEG10 -0.46 Paternally Expressed 10 Validated targets of C-MYC transcriptional activation
CDT1 -0.53 chromatin licensing and DNA replication factor 1 CDK Regulation of DNA Replication,
DYNC1H1 -0.80 dynein, cytoplasmic 1, heavy chain 1
RRM2 -0.72 ribonucleotide reductase M2 polypeptide p53 signaling pathway,…
E2F1 -0.24 E2F transcription factor 1 Pathways in cancer, ….
HAT1 -0.45 histone acetyltransferase 1 Pathway member “HAT1”
CBS -1.20 cystathionine-beta-synthase Cysteine and methionine metabolism,…..
MYC -0.73 v-myc myelocytomatosis viral oncogene homolog (avian) MAPK signaling pathway, ErbB signaling pathway, …….
MCM3 -0.30 minichromosome maintenance complex component 3 DNA replication, Cell cycle