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. 2017 Dec 5;8(67):111882–111901. doi: 10.18632/oncotarget.22948

Figure 1. ICAM-1 deficiency or downregulation promotes MCP-1 expression in mouse lungs and macrophages.

Figure 1

(A) Comparison of MCP-1 expression in WT or ICAM-1-/- mouse lungs by Western blot analysis. MCP-1 is elevated in ICAM-1-/- mouse lungs. (B) Comparison of MCP-1 expression in WT or ICAM-1-/- mouse heart and kidney. MCP-1 expression is relative decreased. (C) In RAW264.7 cells transfected with siRNA-ICAM-1, knockdown of ICAM-1 was measured with Western blot analysis. (D) In RAW264.7 transfected with siRNA-ICAM-1, MCP-1 expression is upregulated as measured with Western blot. (** p <0.01, *** p <0.001).