Table 1. Fitted joint model for overall survival time and response duration on AZA.
| Coefficient | SE | 95% CI | Hazard ratio* / Incidence rate** | 95% CI | P-value | |
|---|---|---|---|---|---|---|
| Cox PH model for OS time* | Hazard ratio | Score (logrank overall) test 0.0095 | ||||
| Male vs Female | -0.906 | 0.453 | -1.795, -0.018 | 0.404 | 0.166, 0.982 | 0.046 |
| Age | -0.006 | 0.030 | -0.065, 0.052 | 0.994 | 0.937, 1.054 | 0.833 |
| CDKN2A mutated>5% | 1.698 | 0.749 | 0.229, 3.166 | 5.461 | 1.258, 23.704 | 0.023 |
| KDM6A mutated>5% | -1.598 | 0.632 | -2.836, -0.360 | 0.202 | 0.059, 0.698 | 0.011 |
| TP53 increasing | -1.489 | 0.673 | -2.808, -0.169 | 0.226 | 0.060, 0.845 | 0.027 |
| 5q- | -1.496 | 0.495 | -2.466, -0.525 | 0.224 | 0.085, 0.592 | 0.003 |
| Poisson count model for Response duration** | Incidence rate | Likelihood ratio (overall) test <.0001 | ||||
|---|---|---|---|---|---|---|
| Sex (Female as intercept) | 0.324 | 0.887 | -1.413, 2.062 | 1.383 | 0.243, 7.869 | 0.715 |
| Male vs Female | 1.141 | 0.179 | 0.791, 1.491 | 3.130 | 2.205, 4.442 | <.0001 |
| Age | 0.006 | 0.012 | -0.018, 0.029 | 1.006 | 0.982, 1.030 | 0.637 |
| ASXL1 mutated>5% | 1.137 | 0.249 | 0.650, 1.624 | 3.118 | 1.915, 5.075 | <.0001 |
| ASXL1 increasing | -1.665 | 0.452 | -2.550, -0.779 | 0.189 | 0.078, 0.459 | 0.0002 |
| BCOR mutated>5% | -1.079 | 0.337 | -1.739, -0.420 | 0.340 | 0.176, 0.657 | 0.001 |
| BCOR increasing | 1.699 | 0.384 | 0.947, 2.451 | 5.467 | 2.577, 11.597 | <.0001 |
| BCORL1 increasing | -0.576 | 0.224 | -1.015, -0.137 | 0.562 | 0.362, 0.872 | 0.010 |
| CDKN2A mutated>5% | -2.750 | 0.481 | -3.693, -1.808 | 0.064 | 0.025, 0.164 | <.0001 |
| CUX1 mutated>5% | 1.981 | 0.361 | 1.274, 2.687 | 7.248 | 3.576, 14.691 | <.0001 |
| CUX1 increasing | -3.105 | 0.435 | -3.957, -2.254 | 0.045 | 0.019, 0.105 | <.0001 |
| EZH2 mutated>5% | -3.304 | 0.529 | -4.340, -2.267 | 0.037 | 0.013, 0.104 | <.0001 |
| KDM6A increasing | 1.209 | 0.398 | 0.429, 1.989 | 3.350 | 1.536, 7.308 | 0.002 |
| RUNX1 mutated>5% | 0.863 | 0.192 | 0.486, 1.240 | 2.370 | 1.625, 3.454 | <.0001 |
| TP53 mutated>5% | 1.733 | 0.537 | 0.680, 2.786 | 5.658 | 1.974, 16.211 | 0.001 |
| TP53 increasing | -1.022 | 0.501 | -2.004, -0.040 | 0.360 | 0.135, 0.960 | 0.041 |
| 5q- | 1.254 | 0.185 | 0.892, 1.616 | 3.503 | 2.440, 5.031 | <.0001 |
(A) Cox PH model for OS time; Score (logrank overall) test.0012.
(B) Poisson count model for Response duration; Likelihood ratio (overall) test <.0001.
SE indicates standard error; CI confidence interval; HR hazard ratio; IR incidence rate.
* A positive (negative) coefficient estimate in the Cox PH model corresponds to a higher (lower) risk of death and thus on average a shorter (longer) OS time.
** A positive (negative) coefficient estimate in the Poisson count model corresponds to higher (smaller) number of months of response duration.