Table 6. Cumulative effects of variant alleles rs10830963 and rs1799884 on GDM susceptibility.
| Number of risk alleles | GDM N (%) |
Controls N (%) |
OR (95% CI) | P | OR (95% CI)* | P* |
|---|---|---|---|---|---|---|
| 0 | 55 (19.8) | 78 (43.6) | 1 | 1 | ||
| 1-2 | 202 (72.7) | 96 (53.6) | 3.0 (2.0 –4.5) | <0.001 | 3.4 (2.1 –5.5) | <0.001 |
| 3-4 | 21 (7.6) | 5 (2.8) | 5.9 (2.1 – 16.7) | 0.001 | 5.1 (1.7 – 15.3) | 0.004 |
| P trend | <0.001 | <0.001 |
*Logistic regression analyses adjusted for age, pre-gestational BMI and the levels of triglycerides, HDL-C and VLDL-C.
Legend: Women with ‘0’ alleles carried no minor alleles of the two SNPs; women with ‘1-4’ alleles carried 1 to 4 variant alleles of the above-stated SNPs.