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. 2017 Dec 1;8(67):112145–112151. doi: 10.18632/oncotarget.22841

Figure 1. The effect of apelin/APJ system blockade on liver fibrosis and liver regeneration.

Figure 1

F13A, apelin-13(F13A); PDGFRβ, platelet-derived growth factor receptor β; ɑ-SMA, ɑ-smooth muscle actin; TIMP, tissue inhibitor of matrix metalloproteinase; MMP, matrix metalloproteinase; HSCs, hepatic stellate cells; ECM, extracellular matrix; STAT3, signal transducer and activator of transcription 3; ERK, extracellular signal-related kinase; TNF, tumor necrosis factor; IL-6, interleukin-6; ↓, decrease. Green arrow denotes stimulation. Red arrow denotes suppression.