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Domain structures of Tmod and Lmod. Tpm1, Tpm2: tropomyosin-binding sites; A1, A2, A3: actin-binding sites, and LRR: leucine-rich repeats. Insets show the sequence alignments between Tmod isoforms, where conserved residues between isoforms are highlighted. The location of the mutations and truncations that disrupt actin binding are shown with asterisk or underlined, respectively. Dashed lines show the locations, where Lmod2 was truncated.
